Is DMAA Safe for Fat Loss?
Fat Burner Ingredients
There are literally hundreds of plants, remedies and supplements out that that are reported to help you achieve your weight loss goals. The problem is of course that some work better than others- and some just don’t work at all.
Synephrine is a popular supplement on the weight loss market, with many brands choosing to include it as part of their fat burner ‘stack’ of ingredients. You’ll also see it included on these supplements by the names bitter orange and citrus aurantium.
Many of these supplements claim to promote healthy weight loss as well as support optimal physical performance- but many people don’t currently understand how or even if it works.
Here we discuss why this nutrient may not be the best choice for your weight loss goals- and may even be unsafe.
Read more to find out:
The bitter orange tree can be found is many warm climate areas, but is originally native to Eastern Africa and parts South East Asia. It is a 10 meter tree when fully mature, with dark green leaves, white flowers and a vibrant orange fruit.
Alternative names for this nutrient include ‘citrus aurantium’, ‘C. aurantium‘ as well as the more common names ‘Seville‘ and ‘Sour‘ orange.
As a supplement, you’ll usually find it in fat burners and stimulants, and it’s typically marketed to promote the following benefits:
But it’s not just in supplements…
As a natural product, practically all parts of the tree are used in various medicines- this includes the leaf, flower and fruit.
Due to the bitter taste, the fruit is not usually eaten, however extract from the peel is used to flavor a range of foods and drinks (both alcoholic and non-alcoholic), as well as make the oil used in supplements.
Bitter orange is used in a number of products including aromatherapy, foods, medicines and cosmetics largely due to its reported anti-fungal, anti-inflammatory and bacterial properties.
Traditionally it has been used in Chinese and Amazonian medicine for a number of medicinal needs including stomach complaints, nausea, diarrhea and constipation. Additionally it has been used as treatment for skin diseases and some cancers, as well as anxiety and insomnia.
So do these reported health benefits make it a potent fat burner?
The bitter orange plant contains many phtyochemicals– these are the biologically active compounds found in plants that provide nutrients and color [1].
The fruit contains a number of organic compounds, but the main one is the stimulant synephrine, or p-synephrine– similar in structure to ephedrine [2] and ephedra.
The alkaloids in this nutrient have been reported to increase energy expenditure, decrease appetite and increase metabolism therefore has been implicated as a weight loss supplement as well.
So that sounds promising right?
Well, not really– as with a lot of these compounds, research is limited so its effects have not been repeatedly tested under strict conditions. Much of the research that has been conducted has been privately funded too [3]. This makes it difficult to look at research results objectively.
The most comprehensive study to date [4] which analysed all existing research on this nutrient, demonstrated no statistically significant benefit for weight loss, and provided limited information about safety either.
Key Points:
Firstly its worth mentioning that taking amounts found naturally in food are unlikely to cause many side effects- but due to the fruit being so bitter, its unlikely that you’ll be able to eat it.
However, issues start to arise when you are taking concentrated amounts as found in supplements containing synephrine.
Remember that it’s also chemically similar to both ephedrine and ephedra- both banned by The U.S. Food and Drug Administration. This is due to links with blood pressure, heart attacks and stroke, and it’s also banned by the National Collegiate Athletic Association (NCAA) due to affects on health.
There are a number of case reports and studies that have reported negative effects of synephrine supplementation.
One case [5], a report of a previously healthy 24 year old man, found that using a fat burner containing the ingredient caused a STEMI- essentially a heart attack caused by a thrombus in his coronary artery, within hours of usage…
…and this was someone who had NO risk factors for coronary artery or heart disease!
Likewise, another study [2] reported a case where a 38-year old woman suffered a stroke after using another synephrine-containing supplement for one week. Again, she had no previous history or risk factors. The study concluded that using supplements of this kind could cause ischemic stroke in healthy individuals.
This nutrient is typically used alongside a number of other ingredients and rarely in isolation. For this reason it is important to be aware of potential interactions.
For example, one case [6] involving a 52-year old woman, reported the emergence of unremitting tachycardia– rapid heart rate without cause, after taking a dietary, bitter orange extract-containing supplement (500mg, synephrine 30mg per day) alongside long-term thyroid medication.
Caffeine- Similarly to ephedrine, it appears to be especially dangerous when taken alongside caffeine according to the German Federal Institute for Risk Assessment (BfR) [7]-
Many bitter orange supplements contain a combination of synephrine and caffeine and therefore may not comply with current regulations- this could classify them as unsafe.
Other side effects-
As well as the very serious side effects of heart attacks and strokes here are a number of other side effects:
Key Points:
There is.
It’s important that you choose to use ingredients that are safe and also proven to work.
Instant Knockout is an industry-leading fat burner that helps you achieve fat loss goals by boosting your metabolism in a safe way. Using exhaustively researched ingredients, including cayenne pepper and green tea extract and a host of vitamins as well as many other nutrients.
It’s even been endorsed by multiple MMA fighters, who have seen benefits such as:
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